Methoxychlor enhances degranulation of murine mast cells by regulating FcϵRI-mediated signal transduction
نویسندگان
چکیده
منابع مشابه
Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms.
Th2-type cytokines and TNF-α secreted by activated mast cells upon cross-linking of FcεRI contribute to the development and maintenance of Th2 immunity to parasites and allergens. We have previously shown that cytokine secretion by mouse mast cells is enhanced by signaling through Notch receptors. In this study, we investigated the molecular mechanisms by which Notch signaling enhances mast cel...
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Signaling through the high affinity receptor for immunoglobulin E (Fc epsilon RI) results in the coordinate activation of tyrosine kinases before calcium mobilization. Receptors capable of interfering with the signaling of antigen receptors, such as Fc epsilon RI, recruit tyrosine and inositol phosphatases that results in diminished calcium mobilization. Here, we show that antibodies recognizin...
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Mast cell function and dysregulation is important in the development and progression of allergic and autoimmune disease. Identifying novel proteins involved in mast cell function and disease progression is the first step in the design of new therapeutic strategies. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of proteins demonstrated to mediate th...
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Mast cells are major players in allergic responses. IgE-dependent activation through FcεR leads to degranulation and cytokine production, both of which require Gab2. To clarify how the signals diverge at Gab2, we established Gab2 knock-in mice that express Gab2 mutated at either the PI3K or SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) binding sites. Examination of these mutants s...
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Interleukin (IL)-25 is a recently described T helper 2 (Th2) cell-derived cytokine that belongs to IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cells (BMMCs) were stimulated by IgE cross-linking, IL-25 mRNA was induced within 30 min i...
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ژورنال
عنوان ژورنال: Journal of Immunotoxicology
سال: 2014
ISSN: 1547-691X,1547-6901
DOI: 10.3109/1547691x.2014.962122